Ngomhla we-10 kweyoKwindla, ngo-2026, i-B7-H3-target antibody-drug conjugate (ADC) YL201 entsha yokujova, eyaphuhliswa yiMediLink Therapeutics, yanikwa iBreakthrough Therapy Designation yiZiko loVavanyo lwaMayeza le-China's National Medical Products Administration. Esi sibonakaliso sidityaniswe neSerplulimab kunyango lokuqala lomhlaza wemiphunga weeseli ezincinci (ES-SCLC).
I-YL201 yi-ADC entsha ejolise ngokukodwa kwi-B7H3. Iproteni ye-B7H3 isetyenziswa kakhulu kwiiseli ezinobungozi kunye neeseli eziqala umhlaza zeentlobo ezahlukeneyo zethumba kodwa inokubonakaliswa okulinganiselweyo kwizicubu eziqhelekileyo, nto leyo egxininisa amandla ayo njengeyeza le-ADC. I-YL201 yaphuhliswa kusetyenziswa itekhnoloji ye-MediLink's Tumor Microenvironment Activable LINKer-payload (TMALIN®) edityaniswe ne-antibody ye-B7H3 ekhethekileyo. Okwangoku, i-YL201 iphandwa kwiintlobo ngeentlobo zethumba eziqinileyo kwaye ingenele uvavanyo oluphambili kwi-Small Cell Lung Cancer kunye ne-Nasopharyngeal Carcinoma eTshayina.
### Idatha yeKliniki eQinisekisiweyo: Ukusebenza okuBalulekileyo kunye noKhuseleko oluLungileyo
NgoMatshi 2025, ijenali yehlabathi ephezulu *Nature Medicine* yapapasha idatha evela kuvavanyo lweklinikhi lweSigaba 1/1b lwe-YL201 kwizigulane ezineethumba eziqinileyo eziphucukileyo. Olu phononongo, oluquka izigulane ezingama-312, lubonise oku:
- **Ukusebenza Ngokupheleleyo:** Phakathi kwezigulane ezingama-287 ezivavanyiweyo, izinga lokuphendula elijolise ngqo (ORR) laliyi-40.8% ephawulekayo, kuquka izigulane ezi-2 ezifumene impendulo epheleleyo (CR) kunye ne-115 ezifumene impendulo engaphelelanga (PR). Izinga lokulawula isifo (DCR) lifikelele kwi-83.6%.
- **Umhlaza Wemiphunga Weeseli Ezincinci Ezikwinqanaba Elibanzi (ES-SCLC):** Kwizigulana ezazinyangwa nge-chemotherapy esekelwe kwiplatinum ngaphambili, i-ORR yayiyi-63.9%, i-DCR yayiyi-91.7%, kwaye i-median progression-free survival (mPFS) yayiyiinyanga eziyi-6.3.
- **I-Nasopharyngeal Carcinoma (NPC):** Phakathi kwezigulane ezingama-70, i-ORR yayiyi-48.6%, i-DCR yayiyi-92.9%, kwaye izigulane ezi-2 zifumene impendulo epheleleyo. Ubude bexesha eliphakathi lempendulo (mDOR) belide kangangeenyanga eziyi-8.4.
Ezi datha ziqinisekisa ngokupheleleyo umsebenzi onamandla wokulwa nethumba kunye neprofayili yokhuseleko elawulekayo ye-YL201 kwiintlobo ezininzi zeethumba eziqinileyo eziphambili, zibeka isiseko esiqinileyo sophando lweklinikhi olulandelayo kunye nokusetyenziswa ngokubanzi.
### ISebe leMicimbi yeHlabathi leSibhedlele se-Oncology saseBeijing South Region: Ibhulorho yakho eya kwiNyango yeHlabathi
ISebe leMicimbi yeHlabathi leSibhedlele i-Oncology saseBeijing South Region lihlala lizinikele ekuziseni ubuchwepheshe kunye namayeza ahamba phambili kwihlabathi liphela okuxilongwa komhlaza kunye nonyango. Silandela ngokusondeleyo inkqubela phambili yophando oluphambili kwaye sigcina intsebenziswano eqinileyo namaziko esayensi aphezulu ngaphakathi nangaphandle, sizama ukubonelela izigulane zamazwe ngamazwe ngokufikelela ngexesha elifanelekileyo kwiindlela zonyango eziphambili kubandakanya i-YL201.
Iqela lethu leeNkonzo zeZigulane zaMazwe ngaMazwe lingakunika oku kulandelayo:
- **Uvavanyo lwezonyango oluKhethekileyo:** Iqela leengcali ezahlukeneyo (i-MDT) liza kuvavanya ngokupheleleyo iirekhodi zakho zonyango ukuze libone ukuba unyango lwe-ADC lufanelekile na kwimeko yakho.
- **Ukufikelela kwiNkathalo okuLungelelanisiweyo:** Uncedo lokufumana ii-visa zokuya eTshayina, ukucwangcisa iingxoxo zeengcali, ukulungiselela iinkonzo zokutolika, kunye nokulungelelanisa ukwamkelwa esibhedlele ukuze ufumane amava angenaxhala.
### Qhagamshelana Nathi Ngoku Ukuze Ufumane Ulwazi Oluthe Ngakumbi
Ukuba wena okanye umntu omthandayo ujongene nemingeni enxulumene nomhlaza wemiphunga weeseli ezincinci ezikwinqanaba eliphezulu, i-nasopharyngeal carcinoma, okanye ezinye iithumba eziqinileyo eziphucukileyo, kwaye unqwenela ukufunda iinkcukacha ezithe vetshe malunga nonyango lwe-ADC oluphambili okanye ukuvavanya amathuba onyango, nceda unxibelelane neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region ngoko nangoko. Iingcali zethu zeNkonzo yezigulana zamazwe ngamazwe ziya kuphendula umbuzo wakho zingadlulanga iiyure ezingama-24.
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- **Umnxeba:** 400-880-3716���
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100085_010@163.com
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Siyaqonda ukuba indlela yonyango lomhlaza inzima, kodwa yonke into eyenzekileyo ibonisa ithemba elitsha. ISebe leMicimbi yeHlabathi leSibhedlele i-Oncology saseBeijing South Region linqwenela ukuma nani, lisebenzisa ubuchwepheshe bezonyango obungcali kunye nokhathalelo olufudumeleyo nolunobubele, ukuze niboyise umhlaza kunye nokwamkela ukuqala kobomi.
Ixesha leposi: Matshi-24-2026