Kutshanje, iZiko loVavanyo lwaMayeza (i-CDE) le-National Medical Products Administration (i-NMPA) yaseTshayina libhengeze ukuba i-Encorafenib ivunyiwe okwethutyana ukuba ihlolwe kuqala. Iza kusetyenziswa kunye ne-cetuximab kunye ne-FOLFOX chemotherapy regimen njengonyango lokuqala kwizigulane zabantu abadala abanomhlaza we-BRAF V600E-mutant metastatic colorectal cancer.
Oku kubonisa inkqubela phambili ebalulekileyo kunyango kuluntu lwezonyango lwamazwe ngamazwe kulo mhlaza onzima ukunyangwa oqhutywa lutshintsho oluthile lwemfuza.
**Yintoni i-Encorafenib kwaye kutheni ibalulekile?**
I-Encorafenib sisithinteli se-BRAF esincinci esikhetha kakhulu, esikhuphisana ne-ATP. Ngamazwi alula, ijolise ngqo kwiiseli ze-tumor ezithwala utshintsho lwe-BRAF V600E, ithintela ukukhula kwazo kunye nokwanda kwazo. Xa kuthelekiswa nezinye izithinteli ze-BRAF ezamkelweyo ngaphambili, i-Encorafenib inomsebenzi omde we-pharmacodynamic, oko kuthetha ukuba ihlala isebenza emzimbeni ixesha elide.
**Idatha yezonyango: Ubungqina bokusebenza kakuhle**
Ngomhla wama-25 kweyoMqungu, ngo-2025, *iNature Medicine* yapapasha uphando lweklinikhi lweSigaba sesi-3 lwe-Encorafenib + Cetuximab + chemotherapy yonyango lomhlaza we-colorectal oguqulwe yi-BRAF. Uphononongo lwe-BREAKWATER (NCT04607421) lujolise ekuvavanyeni ukusebenza kakuhle kwe-encorafenib kunye ne-cetuximab ene-chemotherapy eqhelekileyo okanye engenayo kwizigulane ezine-BRAF V600E-mutant colorectal cancer. Izigulane ezingama-236 zizonke zafakwa kwiqela lovavanyo kwaye ezingama-243 zafakwa kwiqela lolawulo. Iziphumo zibonise izinga lokuphendula eliqinisekisiweyo (cORR) lama-60.9% kwiqela lovavanyo, kunye nezigulane ezi-3 ezifumene impendulo epheleleyo (CR), iimpendulo ezipheleleyo ezingama-64 (PR), kunye nesifo esizinzileyo ezingama-31 (SD). Kwiqela lolawulo, i-cORR yayiyi-40.0%, kunye ne-CR ezi-2, i-PR ezingama-42, kunye ne-SD ezingama-34. Ubude bexesha eliphakathi lokuphendula (DOR) yayiziinyanga ezili-13.9 kunye neenyanga ezili-11.1, ngokwahlukeneyo. Ukusinda okuphakathi ngokubanzi bekungaqikelelwa kwiqela lovavanyo, xa kuthelekiswa neenyanga ezili-14.6 kwiqela lolawulo.
**Kwizigulana Zamazwe Ngamazwe: ISebe Lehlabathi Lesibhedlele Se-Oncology saseBeijing South Region libonelela ngoNyango Oluphezulu**
Olu hlobo lonyango oluphucukileyo ngoku lungene kwindlela yokujonga kuqala eTshayina. Kwizigulane zamazwe ngamazwe—ukuba wena okanye ilungu losapho lifuna iindlela zonyango ezingcono—iSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region lizimisele ukusebenza njengebhulorho kwitekhnoloji yezonyango ephucukileyo yehlabathi. Silandela ngokusondeleyo uphuhliso lwamayeza lwamazwe ngamazwe kwaye sinikezela ngeengcebiso zobungcali kunye noncedo lwezonyango kwizigulane ezifanelekileyo.
**Nxibelelana Nathi Namhlanje Ukuze Uqalise Uhambo Lwakho Lwethemba**
Musa ukulinda. Lonke ithuba lonyango linokukwazi ukutshintsha indlela yobomi. Iqela lethu leenkonzo ezithetha iilwimi ezininzi likulungele ukubonelela ngeengcebiso, ucwangciso lweentlanganiso, kunye nesikhokelo sezonyango.
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Ungasifikelela nangayiphi na indlela kwezi zingentla. Abaququzeleli bethu bezigulane bamazwe ngamazwe baza kuphendula ngokukhawuleza ukunceda ngokucwangciswa kweerekhodi zonyango, uvavanyo lweendlela zonyango, kunye nayo nayiphi na imibuzo malunga nokufuna unyango eBeijing. ISebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region International likulungele ukujongana nemingeni nawe, ngobungcali nangovelwano.
Ixesha leposi: Epreli-23-2026