I-Hyperthermia yoKususwa kweTumor: Ityala loNyango loMhlaza wePancreatic kunye noPhando

Umhlaza wePancreatic inezinga eliphezulu lomhlaza kwaye i-prognosis yayo ayilunganga. Kwimisebenzi yezonyango, uninzi lwezigulane lufunyaniswa lukwinqanaba eliphezulu, kwaye amazinga otyando aphantsi kwaye akukho ndlela yonyango ikhethekileyo. Ukusetyenziswa kwe-HIFU kunokunciphisa ngempumelelo umthwalo wethumba, kulawule iintlungu, ngaloo ndlela kwandise ixesha lokuphila kwesigulana kwaye kuphucule umgangatho wobomi.

Imbali yeHyperthermiaiithumba zinokulandelelwakwiminyaka eyi-5,000 eyadlulayokwiYiputa yamandulo, kunye neengxelo ezikwimibhalo-ngqangi yamandulo yaseYiputa ezichaza ukusetyenziswaubushushu bokunyanga iithumba zamabele.Umsunguli weunyango lobushushu, uHippocrates, othathwa njengoyise wezonyango zaseNtshona, wayephila kwiminyaka emalunga nama-2,500 eyadlulayo.

I-Hyperthermia yindlela yonyango equka ukusebenzisa imithombo eyahlukeneyo yokufudumeza(ezifana ne-radiofrequency, i-microwave, i-ultrasound, i-laser, njl.njl.)ukonyusa ubushushu bezicubu zethumba ukuya kwinqanaba elisebenzayo lonyango. Oku kunyuka kobushushu kukhokelela ekufeni kweeseli zethumba ngelixa kunciphisa umonakalo kwiiseli eziqhelekileyo.

Ngo-1985, i-US FDA yaqinisekisa utyando, unyango ngemitha, i-chemotherapy, i-Hyperthermia, kunye ne-immunotherapy njengeiindlela zesihlanu ezisebenzayo zonyango lwe-tumor, emele indlela entsha nesebenzayo.

Umgaqo osisiseko kukusebenzisa amandla omzimba ukufudumeza umzimba wonke okanye indawo ethile yomzimba, ukunyusa ubushushu bezicubu zethumba ukuya kwinqanaba elifanelekileyo lokunyanga nokuligcina ixesha elithile. Ngokusebenzisa umahluko ekunyamezeleni ubushushu phakathi kwezicubu eziqhelekileyo kunye neeseli zethumba, ijolise ekufezekiseni injongo yokubangela i-apoptosis yeeseli zethumba ngaphandle kokonakalisa izicubu eziqhelekileyo.

Ityala 1 loNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, elineminyaka engama-46 ubudala, linesimila emsileni wepancreas

Ububanzi bethumba buyi-34mm (i-anteroposterior), i-39mm (i-transverse), kunye ne-25mm (i-craniocaudal). Emva konyango lwe-thermal ablation olukhokelwa yi-ultrasound,I-MRI elandelayo ibonise ukuba uninzi lwethumba belungasebenzi.

Ityala lesi-2 loNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, elineminyaka engama-56 ubudala, umhlaza wepancreatic one-metastases yesibindi ezininzi

Unyango ngaxeshanye lwe-pancreatic kunye ne-liver metastases kusetyenziswa unyango lwe-thermal ablation olukhokelwa yi-ultrasound.I-MRI elandelayo ibonise ukuba ithumba alisebenzi, kunye nemida ecacileyo nechanekileyo.

Ityala lesi-3 loNyango loMhlaza wePancreatic:

Isigulana: Indoda, eneminyaka engama-54 ubudala, umhlaza wepancreatic

Intlungu iphelile ngokupheleleyo kwiintsuku ezimbiniemva konyango lwe-HIFU (high-intensity focused ultrasound).Ithumba lehle ngama-62.6% kwiiveki ezi-6, ngama-90.1% kwiinyanga ezi-3, kwaye amanqanaba e-CA199 abuyele kwisiqhelo kwiinyanga ezili-12.

Ityala lesi-4 loNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, elineminyaka engama-57 ubudala, umhlaza wepancreatic

I-tumor necrosis yenzekile emva kweentsuku ezi-3 emva konyango lwe-HIFU.Ithumba lehla ngama-28.7% kwiiveki ezi-6, ngama-66% kwiinyanga ezi-3, kwaye intlungu yaphela ngokupheleleyo.

Ityala lesi-5 loNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, elineminyaka engama-41 ubudala, umhlaza wepancreatic

Emva kweentsuku ezili-9 zonyango lwe-HIFU,I-PET-CT scan elandelayo ibonise i-necrosis enkulu embindini wethumba.

Ityala lesi-6 loNyango loMhlaza wePancreatic:

Isigulana: Indoda, eneminyaka engama-69 ubudala, umhlaza wepancreatic

Ukuhlolwa kwe-PET-CT okulandelayo emva kwesiqingatha senyanga emva konyango lwe-HIFUkutyhilwe ukunyamalala ngokupheleleyo kwesi sifo, akukho ukuthathwa kwe-FDG, kwaye emva koko kwehla kwamanqanaba e-CA199.

Ityala lesi-7 loNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, elineminyaka engama-56 ubudala, umhlaza wepancreatic

Uvavanyo lwe-CT olulandelelanayo emva kosuku olunye emva konyango lwe-HIFU luboniseUkususwa kwethumba ngama-80%.

Ityala lesi-8 loNyango loMhlaza wePancreatic:

Uneminyaka engama-57 ubudala, umhlaza wepancreatic

Emva konyango lwe-HIFU, kulandelwa i-CT scankwabonakala ukususwa ngokupheleleyo kwezicubu embindini wesimila.