I-Hyperthermia ye-Tumor Ablation: I-Pancreatic Cancer's Treatment Case kunye noPhando

Umhlaza wePancreatic uneqondo eliphezulu lokugula kunye nokuxilongwa kakubi.Kwinkqubo yeklinikhi, izigulane ezininzi zifunyaniswa kwinqanaba eliphezulu, kunye namazinga aphantsi okuhlinzwa okuhlinzwa kwaye akukho lunye unyango olukhethekileyo.Ukusetyenziswa kwe-HIFU kunokunciphisa ngokufanelekileyo umthwalo wethumba, ukulawula iintlungu, ngaloo ndlela ukwandisa ukusinda kwesigulane kunye nokuphucula umgangatho wobomi.

Imbali yeHyperthermiakuba amathumba angalandelwaemva kweminyaka engama-5,000 eyadlulayoeYiputa yamandulo, kunye neerekhodi kwimibhalo-ngqangi yamandulo yaseYiputa echaza ukusetyenziswa kweukushisa ukunyanga amathumba ebele.Umseki weunyango thermal, uHippocrates, ogqalwa njengoyise wezonyango zaseNtshona, wayephila malunga neminyaka engama-2 500 eyadlulayo.

I-Hyperthermia yindlela yonyango ebandakanya ukusetyenziswa kwemithombo eyahlukeneyo yokufudumeza(ezifana ne-radiofrequency, microwave, ultrasound, laser, njl.)ukunyusa ubushushu bezicubu zethumba ukuya kwinqanaba lonyango olusebenzayo.Oku kunyuka kobushushu kukhokelela ekufeni kweeseli zethumba ngelixa kunciphisa umonakalo kwiiseli eziqhelekileyo.

Ngo-1985, i-US FDA yaqinisekisa utyando, unyango lweradiation, ichemotherapy, iHyperthermia, kunye ne-immunotherapy njenge.iindlela zesihlanu ngempumelelo unyango ithumba, emele indlela entsha nesebenzayo.

Umgaqo osisiseko kukusebenzisa amandla omzimba ukufudumeza umzimba wonke okanye indawo ethile yomzimba, ukuphakamisa ubushushu bobushushu bezicubu zethumba ukuya kwinqanaba lonyango olusebenzayo kunye nokugcina ixesha elithile.Ngokuthatha inzuzo yomahluko wokunyamezelana nobushushu phakathi kwezicubu eziqhelekileyo kunye neeseli zethumba, ijolise ekufezekiseni injongo yokubangela i-apoptosis yeseli yethumba ngaphandle kokonakalisa izicubu eziqhelekileyo.

Imeko yoku-1 yoNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, iminyaka engama-46 ubudala, ithumba kumsila we-pancreas

I-diameter ye-tumor ilinganisa i-34mm (i-anteroposterior), i-39mm (i-transverse), kunye ne-25mm (i-craniocaudal).Ukulandela unyango lwe-thermal ablation olukhokelwa yi-ultrasound,i-MRI yokulandela ibonise ukuba uninzi lwe-tumor lwalungasebenzi.

Imeko yesi-2 yoNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, iminyaka eyi-56 ubudala, umhlaza we-pancreatic kunye ne-metastases ezininzi zesibindi

Unyango ngaxeshanye kuzo zombini i-pancreatic kunye ne-metastases yesibindi usebenzisa i-ultrasound-guided thermal ablation therapy.I-MRI yokulandelela ibonise ukungasebenzi kwe-tumor, kunye nemida ecacileyo kunye nechanekileyo.

Imeko yesi-3 yoNyango loMhlaza wePancreatic:

Isigulana: Indoda, iminyaka eyi-54 ubudala, umhlaza we-pancreatic

Iintlungu ziphelile ngokupheleleyo kwiintsuku ze-2emva kwe-HIFU (i-high-intensity focused ultrasound) unyango.I-tumor yanciphisa nge-62.6% kwiiveki ze-6, i-90.1% kwiinyanga ze-3, kwaye amanqanaba e-CA199 abuyele ngokuqhelekileyo kwiinyanga ze-12.

Imeko yesi-4 yoNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, iminyaka eyi-57 ubudala, umhlaza we-pancreatic

I-necrosis ye-tumor yenzeke kwiintsuku ze-3 emva konyango lwe-HIFU.I-tumor yancipha nge-28.7% kwiiveki ze-6, i-66% kwiinyanga ze-3, kwaye intlungu yakhululwa ngokupheleleyo.

Imeko yesi-5 yoNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, iminyaka eyi-41 ubudala, umhlaza we-pancreatic

Emva kweentsuku ezili-9 zonyango lwe-HIFU,Ukulandelwa kwe-PET-CT scan kubonise i-necrosis ebanzi kwiziko le-tumor.

Kwimeko yesi-6 yoNyango loMhlaza wePancreatic:

Isigulana: Indoda, iminyaka eyi-69 ubudala, umhlaza we-pancreatic

Ukulandelela i-PET-CT scan isiqingatha senyanga emva konyango lwe-HIFUkwatyhila ukunyamalala ngokupheleleyo kwethumba, akukho kuthathwa kwe-FDG, kunye nokuhla okulandelayo kumanqanaba e-CA199.

Imeko yesi-7 yoNyango loMhlaza wePancreatic:

Isigulana: Ibhinqa, iminyaka eyi-56 ubudala, umhlaza we-pancreatic

Ukulandelwa kwe-CT scan ngenye imini emva kokuba unyango lwe-HIFU luboniseI-80% yokukhutshwa kwethumba.

Imeko yesi-8 yoNyango loMhlaza wePancreatic:

Iminyaka engama-57 ubudala, umhlaza we-pancreatic

Emva konyango lwe-HIFU, ukulandelwa kwe-CT scankutyhilwe ukukhutshwa okupheleleyo kumbindi wethumba.