Ivunyiwe yiSevabertinib eTshayina: Unyango olutsha oluchanekileyo lwe-HER2-Mutant NSCLC

Kutshanje, iBayer ibhengeze ukuba i-National Medical Products Administration (NMPA) yaseTshayina ivumile ichiza elitsha elijoliswe kuyo i-sevabertinib lokunyanga izigulane zabantu abadala abanomhlaza wamaphaphu ongengoweseli omncinci (NSCLC) ongenakususwa kwi-local advanced okanye osasazekayo, abane-HER2 (ERBB2) esebenzayo kwiinguqu kwaye baye bafumana ukuqhubela phambili kwesifo emva konyango olunye lwangaphambili.

Oku kuthetha ukuba kungakhathaliseki ukuba uvela kweliphi ilizwe, ngoku ungafikelela kolu nyango luphezulu oluchanekileyo kwihlabathi liphela ngeSebe leZibhedlele ze-Oncology zaseBeijing South Region International.

I-Sevabertinib: Ukujolisa ngqo kwiinguqu ze-HER2

I-Sevabertinib yi-inhibitor entsha, yomlomo, eguqulwayo ye-tyrosine kinase ye-molecule encinci. Ithintela ngamandla i-HER2 eguqulweyo (kuquka ukufakwa kwe-HER2 exon 20 kunye nokuguqulwa kwamanqaku) kunye ne-EGFR. Xa kuthelekiswa nee-TKI zemveli ezingaguqukiyo, i-TKI eguqulwayo ibonelela ngokuvalwa okwethutyana, okuchanekileyo, okuvumela unyango olulawulwayo ngakumbi kwaye kunokunciphisa iziphumo ebezingalindelekanga zexesha elide.

Ukukhuthaza Idatha Yeklinikhi: Iimpendulo Ezibalulekileyo, Iingenelo Ezihlala Ixesha Elide

Ukuvunywa kwe-sevabertinib kusekelwe kwiziphumo ezilungileyo ezivela kuvavanyo lwe-SOHO-01 lweSigaba se-I/II samazwe ngamazwe esinamaziko amaninzi:

- Kwizigulane ezingazange zifumane unyango lwe-ADC olujoliswe kwi-HER2 ngaphambili

Izinga lempendulo echanekileyo (ORR) lifikelele kwi-64%, kuquka iimpendulo ezipheleleyo ze-2.5% kunye neempendulo ezingaphelelanga ze-62%. Ubude obuphakathi bempendulo bebuziinyanga eziyi-9.2.

- Kwizigulane ezazifumene unyango lwe-ADC olujoliswe kwi-HER2 ngaphambili

I-ORR yayisengama-38%, kuquka iimpendulo ezipheleleyo ezingama-5.5% kunye neempendulo ezingaphelelanga ezingama-33%. Ubude obuphakathi bempendulo yayiziinyanga ezisi-7.

Iprofayili yokhuseleko iyalawuleka kwaye ihambelana neengxelo zangaphambili, nto leyo enika isiseko esithembekileyo sonyango lwexesha elide.

Kutheni Ukhetha iSebe leMicimbi yeHlabathi leSibhedlele se-Oncology saseBeijing South Region?

Njengeziko lezonyango lamazwe ngamazwe eligxile kunyango oluchanekileyo lomhlaza, sinikezela ngezigulane zehlabathi:

- Iqela lezonyango elithetha iilwimi ezininzi: Iinkonzo ngesiTshayina, isiNgesi, isiRashiya, isiArabhu, nezinye izinto, ukuqinisekisa unxibelelwano olungenamthungo kulo lonke.

- Iinkonzo zezigulane zamazwe ngamazwe ezinikezelwa kwindawo enye: Ulungelelwaniso oluzinikeleyo ukusuka kwiingcebiso ezikude kunye noncedo lwe-visa yezonyango ukuya ekudluliselweni kwisikhululo seenqwelo-moya, amalungiselelo okulaliswa esibhedlele, kunye nokulandelela emva konyango.

- Izicwangciso zonyango ezenzelwe wena: Unyango olujoliswe kuwe kunye nezicwangciso zolawulo olupheleleyo ezisekelwe kwiprofayili yemfuza yesigulana kunye nemeko iyonke.

Qhagamshelana Nathi Namhlanje Ukuze Uqalise Uhambo Lwakho Lwethemba

ISebe leZizwe ngezizwe leSibhedlele se-Oncology saseBeijing South Region

Inombolo yoNcedo lweSigulana seHlabathi: 400-880-3716

I-WeChat: 17801183037

I-imeyile:

- 100085_010@163.com

- myimmnet@163.com

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Ubomi Bakho Bufanelwe Lunyango Olungcono

Nokuba ufuna umgca wokuqala wethemba okanye sele uqhubekile emva kweendlela ezininzi zangaphambili, i-sevabertinib isenokunika ithuba lokutshintsha elingazange libonwe ngaphambili. ISebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region likulungele ukukuvulela indlela eluhlaza—fowunela ku-400-880-3716 ngoku, okanye unxibelelane nathi nge-WeChat okanye nge-imeyile. Masikuncede uqhagamshelane neengcali eziphambili, uvavanye ukufaneleka, kwaye ucwangcise uhambo lwakho lonyango eTshayina.

Musa ukulinda. Yonke ifowuni inokuba sisiqalo esitsha.

ISebe leMicimbi yeHlabathi leSibhedlele se-Oncology saseBeijing South Region — Ukudibanisa izigulana zehlabathi ngeNyango yaseTshayina eNgcono.