Ngomhla we-12 kuCanzibe, ngo-2025, i-CARsgen ibhengeza idatha yokuqala yeklinikhi ye-CT0596, i-CAR-T ejoliswe kwi-allogeneic BCMA eyenziwe kusetyenziswa iqonga le-THANK-u Plus™. I-CT0596 okwangoku ivavanywa kuphononongo lweklinikhi oluphonononga kwangaphambili i-relapse/refractory multiple myeloma (R/R MM) okanye i-relapse/refractory plasma cell leukemia (R/R PCL) ukuvavanya ukhuseleko lwayo, kunye nokusebenza kwayo kwangaphambili.
Ukususela nge-6 kaMeyi 2025, izigulane ezisi-8 ezine-R/R MM ezazifumene ubuncinane imigca emithathu yonyango ngaphambili zabhaliswa zaza zafakwa i-CT0596 emva kokususwa kwe-lymphocyte nge-regimen ye-FC (i-fludarabine 22.5-30 mg/m² kunye ne-cyclophosphamide 350-500 mg/m²). Iziphumo eziphambili ukusuka kwiinyanga ezine zokulandelela ziquka:
Akukho zityhefu zithintela idosi (ii-DLT), i-≥Grade 3 cytokine release syndrome (ii-CRS), i-immune effector cell-associated neurotoxicity syndrome (ii-ICANS), okanye isifo se-graft-versus-host (ii-GVHD) ezixeliweyo. Le mveliso ibonakalise iprofayili yokhuseleko elungileyo, kungekho zigulana ziyeka unyango ngenxa yeziganeko ezimbi.
1) Phakathi kwezigulana ezi-5 ezigqibe uvavanyo lokuqala lokusebenza kakuhle kwiVeki yesi-4, izigulana ezi-3 (60%) zifumene impendulo epheleleyo/impendulo epheleleyo (sCR/CR), kwaye izigulana ezi-4 (80%) zifumene isifo esincinci esisele (MRD)-ukungakhathali kwithambo lomongo. 2) Idatha yokusebenza kwangoko evela kwizigulana ezi-2 ngoSuku lwe-14 ibonise ukwehla kwizilonda ezinokulinganiswa nge-≥92% kunye ne-≥65%, ngokulandelelana. 3) Isigulana esinye sasingekafikeleli kwixesha lovavanyo lokusebenza kakuhle elichazwe kwiprotokholi.
Zonke izigulane ze-sCR/CR zihlale ziphendula rhoqo, kuquka nesigulana sokuqala esagqiba ukulandelela iinyanga ezine.
Ngokusekelwe kwidatha yokuqala yokhuseleko nokusebenza kakuhle, i-CT0596 ibonakalise ukunyamezeleka okuhle kunye nokukhuthaza imiqondiso yokusebenza kakuhle kwizigulane ze-R/R MM kuzo zonke iinqanaba zedosi ezichazwe kwangaphambili, kunye nokwandiswa kwe-CAR-T okubonweyo. Ezi ziphumo zifuna uphando oluthe kratya kungekuphela nje kwi-R/R MM, kodwa nakwezinye izifo ze-plasma cell kunye nezifo ze-autoimmune ezibangelwa ziiseli ze-plasma ezisebenzayo.
Okwangoku, kusekho iimvavanyo ezininzi zeklinikhi zobuchwepheshe obutsha bokulwa nomhlaza eTshayina obufuna izigulane. Iingcebiso ngamayeza amatsha kunye nobuchwepheshe, ungaqhagamshelana neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region.
Inombolo yefowuni: 4008803716
Email：myimmnet@163.com
Ixesha leposi: Meyi-15-2025