Ekuqaleni kuka-2026, icandelo lonyango lwe-oncology eTshayina liphumelele kakhulu. Ngomhla wesi-5 kweyoMqungu, i-China National Medical Products Administration (NMPA) yavuma ngokusesikweni iyeza elitsha elijoliswe kwisizukulwana iRepotrectinib lokunyanga izigulane zabantu abadala ezinee-solid tumors ezine-neurotrophic tyrosine receptor kinase (NTRK) gene fusions. Olu vunyiweyo luzisa ithemba elitsha kunye neendlela ezahlukeneyo kwizigulane ezininzi ezine-solid tumors ezijongene nemingeni yonyango, ingakumbi abo baye basilela kunyango lwangaphambili okanye abaswele iindlela zonyango ezisebenzayo.
**Malunga ne-Ocapler® (Repotrectinib): Iyeza elijoliswe kwisizukulwana esitsha, elinamandla, nelichanekileyo**
I-Ocapler® (i-Repotrectinib) sisizukulwana esitsha se-tyrosine kinase inhibitor (TKI) eyilwe ngokukodwa ukujolisa ngqo kwi-ROS1 kunye ne-NTRK oncogenic gene fusions. Kwizigulana ezineethumba eziqinileyo (kuquka nomhlaza wemiphunga ongengoweeseli ezincinci, njl.njl.) ezithwala olu tshintsho lwemfuza, i-Repotrectinib ibonisa ukusebenza kakuhle nasemva kokuxhathisa unyango olujoliswe kulo ngaphambili. Ikwalawula ngempumelelo ukusasazeka kwe-brain metastases, inika izibonelelo zonyango ezihlala ixesha elide.
**Idatha Eqinileyo Ebonisa Ukusebenza Okugqwesileyo**
Imvume ye-NMPA isekelwe kuphando olubalulekileyo lweSigaba 1/2 se-TRIDENT-1 sehlabathi. Iziphumo ziyakhuthaza:
- **Kwizigulana ezazinyangwe ngaphambili ngonyango olujoliswe kwi-TRK:** Izinga lokuphendula elijolise ngqo (ORR) lifikelele kwi-50%, kunye nezinga lokulawula isifo (DCR) le-42%.
- **Kwizigulane ezingazange zifumane unyango ngaphambili ezingazange zinyangwe ngonyango olujoliswe kwi-TRK:** Ukusebenza kakuhle kuyamangalisa nangakumbi, kunye nezinga lokuphendula elichanekileyo elifikelela kwi-58%, kuquka izinga lokuphendula ngokupheleleyo (CR) le-15%, oko kuthetha ukuba iithumba zanyamalala ngokupheleleyo kwezinye izigulane. Okuphawulekayo kukuba, ama-83% abaphenduli baqhubeka nokuxhamla kunyaka olandelayo.
Ezi datha zibonisa ngokucacileyo umsebenzi weRepotrectinib onamandla nohlala ixesha elide wokulwa nethumba, kunye neprofayili yokhuseleko elawulekayo, kwizigulane ezine-NTRK fusion-positive solid tumors.
**ISebe leMicimbi yeHlabathi leSibhedlele se-Oncology saseBeijing South Region: Indlela yakho yokungena kwiNkonzo yezeMpilo yeHlabathi**
Njengenye yeziko eziphambili zokuxilonga nonyango lwe-oncology eTshayina, iSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region lihlala liphambili ekulweni nomhlaza. ISebe leMicimbi yezeNyango leHlabathi lithuba lethu elizinikeleyo kwizigulana ezivela kwihlabathi liphela, ezizimisele ukubonelela ngeenkonzo zonyango ezikumgangatho ophezulu nezilungeleleneyo nezihambelana nemigangatho yamazwe ngamazwe.
**Kutheni Ukhetha Thina?**
1. **Ukufikelela kwiiNyango zeHlabathi eziPhezulu:** Silandela ngokusondeleyo iimvume zamva nje zamayeza ehlabathi (ezifana nokuvunywa kwakutshanje kweRepotrectinib), siqinisekisa ukuba izigulane zamazwe ngamazwe zinokufikelela kwiindlela zonyango eziphambili eTshayina ezihambelana nezo zifumaneka eMelika, eYurophu, nakwezinye iindawo.
2. **Iqela leeNgcali eziNxulumene neMicimbi eMininzi (MDT):** Sineqela leengcali elinamava kwiindawo ezahlukeneyo zesifo se-tumor esiqinileyo, kubandakanya umhlaza wemiphunga, i-sarcoma, kunye nomhlaza we-thyroid, elikwaziyo ukubonelela ngoxilongo oluchanekileyo kunye nocwangciso olupheleleyo lonyango lwezigulane ezine-gene fusions ezingaqhelekanga ezifana ne-NTRK.
3. **Iinkonzo zeSigulana saMazwe ngaMazwe eziNto zonke:** Ukususela kwingcebiso yokuqala, uphononongo lweerekhodi zonyango, ishedyuli yentlanganiso, kunye neengcebiso zeengcali ukuya kumalungiselelo onyango, inkxaso yokulaliswa esibhedlele, kunye nonyango olulandelayo, sinikezela ngeenkonzo ezingenazingxaki, ezithetha iilwimi ezininzi, nezinenkathalo kuyo yonke inkqubo.
4. **Ulungelelwaniso lwezonyango oluNqamleza imida:** Siyiqonda kakuhle iimfuno zokuhamba kunye nonxibelelwano lwezigulane zamazwe ngamazwe kwaye sinokubonelela ngoncedo olufunekayo ukuqinisekisa ukuba uhambo lwakho lwezonyango luhamba kakuhle kwaye alunaxhala.
**Nxibelelana Nathi Ngoku Ukuze Uqalise Uhambo Lwakho Lonyango Oluchanekileyo**
Ukuba wena okanye abantu obathandayo nifuna ithemba elitsha lokunyanga ii-NTRK fusion-positive solid tumors, nceda unxibelelane nathi ngoko nangoko. Iqela lethu leengcali leSebe lezeMpilo laMazwe ngaMazwe likulungele ukuvavanya ukufaneleka kwakho kwaye linike isikhokelo sezonyango esineenkcukacha.
- **Umnxeba weZigulana zaMazwe ngaMazwe:** 400-880-3716
- **WeChat/WhatsApp:** +86 17801183037 (I-ID ye-WeChat: 17801183037)
- **I-imeyile:**
100085_010@163.com
myimmnet@163.com
*(Nceda uqaphele: Ukuqinisekisa ukusebenza kakuhle konxibelelwano, xa uthumela iirekhodi zonyango, nceda ukhuphele zombini iidilesi ze-imeyile kwaye ufake inkcazo emfutshane yemeko.)*
**Ingcebiso yesenzo:**
Nceda ulungiselele iingxelo ezifanelekileyo ze-pathological, iingxelo zovavanyo lwe-genetic (ingakumbi ezo ziqulethe iziphumo ze-NTRK gene fusion), kunye neerekhodi zonyango zangaphambili oza kuzibonelela xa unxibelelana nathi. Oku kuya kunceda iingcali zethu zenze uvavanyo lokuqala olukhawulezileyo noluchanekileyo.
ISebe leMicimbi yeHlabathi leSibhedlele i-Oncology saseBeijing South Region lizimisele ukukhusela impilo nobomi bezigulane kwihlabathi liphela ngobuchule bezonyango kunye nokhathalelo olufudumeleyo nolunobubele. Silangazelela ukuva umbuzo wakho.
Ixesha leposi: Jan-08-2026