Unyango Lwesihlanu Lwee-Tumors – Hyperthermia
Xa kufikwa kunyango lwe-tumor, abantu badla ngokucinga ngotyando, i-chemotherapy, kunye nonyango lwe-radiation. Nangona kunjalo, kwizigulane zomhlaza ezikwinqanaba eliphezulu ezilahlekelwe lithuba lotyando okanye ezoyika ukunganyamezelani komzimba kwe-chemotherapy okanye inkxalabo malunga ne-radiation evela kunyango lwe-radiation, ukhetho lwabo lonyango kunye nexesha lokusinda lunokuncipha ngakumbi.
I-Hyperthermia, ukongeza ekusetyenzisweni njengonyango oluzimeleyo lwezimila, ingadityaniswa ne-chemotherapy, unyango lwe-radiation, amayeza esintu aseTshayina, kunye nolunye unyango ukwenza ukuhambelana kwezinto eziphilayo. Iyandisa uvakalelo lwezigulana kwi-chemotherapy, unyango lwe-radiation, kunye namayeza esintu aseTshayina, nto leyo ekhokelela ekuphelisweni ngempumelelo kweeseli ze-tumor ezinobungozi. I-Hyperthermia iphucula umgangatho wobomi kwaye yandise ubomi bezigulane ngelixa inciphisa iziphumo ebezingalindelekanga ezibangelwa lunyango lwe-radiation kunye ne-chemotherapy. Ke ngoko, ibizwa ngokuba yi"Unyango oluluhlaza"luluntu lwezonyango lwamazwe ngamazwe.
Inkqubo ye-RF8 Hyperthermia enamaza e-Electromagnetic akhawulezayo kakhulu
I-THERMOTRON-RF8yinkqubo ye-tumor hyperthermia eyenziwe ngokubambisana yiJapan National Institute of Science and Technology, iKyoto University School of Medicine, kunye neYamamoto VINITA Corporation.
*I-RF-8 inamava angaphezu kweminyaka engama-30 kwezonyango.
*Isebenzisa iteknoloji yamaza e-electromagnetic ye-8MHz eyahlukileyo kwihlabathi liphela.
*Inkqubo yayo yokulawula ubushushu echanekileyo inomda wempazamo ongaphantsi kwe +(-) 0.1 degrees Celsius.
Le nkqubo ilawula ngokufanelekileyo imitha ye-electromagnetic wave ngaphandle kokufuna ukhuselo lwe-electromagnetic.
Isebenzisa uyilo oluncediswa yikhompyutha olusebenzayo ekucwangciseni unyango nasekubekeni iliso ngexesha lenkqubo yonyango.
Iimpawu zeHyperthermia:
Intloko nentamo, amalungu omzimba:Iithumba zentloko nentamo, iithumba zamathambo ezinobungozi, iithumba zezicubu ezithambileyo.
Umqolo Wesifuba:Umhlaza wemiphunga, umhlaza womqala, umhlaza webele, i-mesothelioma embi, i-lymphoma embi.
Umqolo wesinqe:Umhlaza wezintso, umhlaza wesinyi, umhlaza weprostate, umhlaza wamasende, umhlaza wangasese, umhlaza womlomo wesibeleko, umhlaza we-endometrial, umhlaza wesibeleko.
Umqolo Wesisu:Umhlaza wesibindi, umhlaza wesisu, umhlaza wepancreatic, umhlaza we-colorectal.
Iingenelo zeHyperthermia xa zidityaniswe nezinye iindlela zonyango:
I-Hyperthermia:Ngokufudumeza izicubu ezinzulu kwindawo ekujoliswe kuyo ukuya kuma-43 degrees Celsius, ukubola kweproteni kwenzeka kwiiseli zomhlaza. Unyango oluninzi lunokukhokelela kwi-apoptosis yeeseli zomhlaza kwaye lutshintshe imeko-bume yezicubu zasekuhlaleni kunye ne-metabolism, okubangela ukwanda kwemveliso yeeproteni zokutshisa ubushushu kunye nee-cytokines, ngaloo ndlela kukhulisa umsebenzi wokuzikhusela.
I-Hyperthermia + I-Chemotherapy (Efakwa kwi-Intravenous):Kusetyenziswa isinye kwisithathu ukuya kwisiqingatha sedosi yekhemotherapy eqhelekileyo, ukunikezelwa kwe-intravenous symnized kwenziwa xa ubushushu bomzimba obuphantsi bufikelela kwi-43 degrees Celsius. Oku kwandisa uxinaniso lwamayeza asekuhlaleni kunye nokusebenza kakuhle ngelixa kunciphisa iziphumo ebezingalindelekanga zekhemotherapy. Ingazanywa njengokhetho lwekhemotherapy "olunciphisiweyo" kwizigulana ezingafanelekanga kwikhemotherapy yendabuko ngenxa yeemeko zazo zomzimba.
I-Hyperthermia + Ukuphalaza (Ukuphalaza Kwesifuba Nesisu):Ukunyanga i-pleural kunye ne-peritoneal effusions ezinxulumene nomhlaza kunzima. Ngokuqhuba i-hyperthermia kunye nokugalela ii-chemotherapeutic agents ngaxeshanye ngeetyhubhu zokuhambisa amanzi, iiseli zomhlaza zinokutshatyalaliswa, kuncitshiswe ukuqokelelana kolwelo kwaye kuncitshiswe iimpawu zesigulana.
Unyango lweHyperthermia + iRadiation:Unyango lwemitha alusebenzi kakuhle kwiiseli ezikwisigaba se-S, kodwa ezi seli ziyasabela kubushushu. Ngokudibanisa i-hyperthermia kwiiyure ezine ngaphambi okanye emva konyango lwemitha, unyango lunokuqinisekiswa kuzo zonke iiseli ezikwizigaba ezahlukeneyo zomjikelo weseli ngosuku olunye, nto leyo ekhokelela ekunciphiseni okunokwenzeka kwe-1/6 kwidosi yemitha.
Imigaqo kunye nemvelaphi yoNyango lweHyperthermia
Igama elithi “Hyperthermia” livela kwigama lesiGrike, elithetha “ubushushu obuphezulu” okanye “ubushushu obugqithisileyo.” Libhekisa kwindlela yonyango apho kusetyenziswa khona imithombo eyahlukeneyo yobushushu (i-radiofrequency, i-microwave, i-ultrasound, i-laser, njl.njl.) ukunyusa ubushushu bezicubu zethumba ukuya kwinqanaba elifanelekileyo lokunyanga, okubangela ukufa kweeseli zethumba ngelixa kusindisa iiseli eziqhelekileyo ekonakalisweni. I-Hyperthermia ayibulali nje kuphela iiseli zethumba kodwa ikwaphazamisa imeko-bume yokukhula kunye nokuzala kweeseli zethumba.
Umseki we-hyperthermia unokulandelwa emva kuHippocrates kwiminyaka engama-2500 eyadlulayo. Ngenxa yophuhliso olude, kuye kwabhalwa amatyala aliqela kwizonyango zanamhlanje apho iithumba zanyamalala emva kokuba izigulana zifumene umkhuhlane ophezulu. Ngo-1975, kwi-International Symposium on Hyperthermia eyayibanjelwe eWashington, DC, i-hyperthermia yaqatshelwa njengendlela yesihlanu yokunyanga iithumba ezinobungozi.Yafumana isiqinisekiso se-FDA ngo-1985.Ngowama-2009, uMphathiswa wezeMpilo waseTshayina wakhupha i-“Management Specification for Local Tumor Hyperthermia and New Technologies,” nto leyo eyaqinisa i-hyperthermia njengenye yeendlela ezibalulekileyo zonyango olupheleleyo lomhlaza, kunye notyando, unyango ngemitha, i-chemotherapy, kunye ne-immunotherapy.
Uhlolo lweTyala
Ityala 1: Isigulana esine-metastasis yesibindi esivela kwi-renal cell carcinomaufumene unyango lwe-immunotherapy iminyaka emi-2 waza wafumana iiseshoni ezingama-55 ezidibeneyo ze-hyperthermia. Okwangoku, imifanekiso ibonisa ukunyamalala kweethumba, iimpawu zethumba ziye zehla zaya kumanqanaba aqhelekileyo, kwaye ubunzima bomguli bunyuke ukusuka kwiikhilogram ezili-110 ukuya kwiikhilogram ezili-145. Banokuphila ubomi obuqhelekileyo.
Ityala lesi-2: Isigulana esine-pulmonary mucinous adenocarcinomaufumene ukuqhubela phambili kwesifo emva kotyando, unyango ngemitha, unyango olujoliswe kulo, kunye nonyango lwe-immunotherapy. Umhlaza wawune-metastasis ebanzi ene-pleural effusion. Unyango olukhawulezayo lwe-ion oludityaniswe nonyango oluphambili lwe-immunotherapy lwaqaliswa kwiiveki ezintathu ezidlulileyo. Unyango aluzange lubonise ziphumo ebezingalindelekanga, kwaye isigulane asinangxaki ingako. Olu nyango lumele ithuba lokugqibela lesigulana.
Ityala lesi-3: Isigulana esinomhlaza wesisu emva kotyandookwanyanzeleka ukuba bayeke unyango olujoliswe kubo ngenxa yomonakalo omkhulu wolusu. Emva kokugqiba iseshoni enye yonyango lwe-ion olukhawulezayo, isigulane safumana i-11ubunzima beekhilogram.
Ixesha lokuthumela: Agasti-04-2023