Kutshanje, isigulane esinomhlaza wepancreatic oqhubele phambili nowawungazange uphumelele kwiindlela ezininzi zonyango lwangaphambili sifumene ukuncitshiswa kwethumba emva kokufumana unyango lweeseli ze-KD-496 CAR-T, kwaye ukukhululwa okuqinisekisiweyo kugcinwe kwiintsuku ezili-180 emva konyango.
Okwangoku, kusekho iimvavanyo ezininzi zeklinikhi zobuchwepheshe obutsha bokulwa nomhlaza eTshayina obufuna izigulane. Iingcebiso ngamayeza amatsha kunye nobuchwepheshe, ungaqhagamshelana neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region.
Inombolo yefowuni: 4008803716
I-ID ye-WeChat: 17801183037
I-imeyile：myimmnet@163.com
Isigulana, ibhinqa elineminyaka engama-73 ubudala, safunyaniswa ngoJulayi 2021 sinentloko yepancreatic exineneyo kunye nokuvaleka kwe-bile duct ephantsi. Saye sahlinzwa i-duodenectomy, apho kwafunyanwa khona ubunzima obuqinileyo obumalunga ne-3 cm ngobukhulu kwinkqubo yokukhupha intloko yepancreatic. Uvavanyo lwe-pathological luqinisekisile ukuba i-adenocarcinoma yahlulwe kancinci. Emva kotyando, safumana i-albumin-bound paclitaxel (nab-paclitaxel) edityaniswe ne-S-1 chemotherapy, kwalandela i-M108 + nab-paclitaxel + gemcitabine kunye ne-LM108 edityaniswe ne-toripalimab. Sasinembali ye-schizophrenia kunye nesifo seswekile, zombini ezilawulwa kakuhle ngamayeza.
NgoFebruwari 2025, isigulana safumana utyando lweeseli ze-KD-496 CAR-T. Kuvavanyo lokuqala lwethumba emva kweeveki ezine, nangona wayesele ekhulile kwaye enomthwalo omkhulu wethumba (i-baseline target lesion ye-58 mm), i-target lesion yayinciphile ngama-34.5% ukusuka kwi-baseline lesion. Ngomhla wama-60, i-target lesion yayinciphile ngama-37.9%, kwaye ngomhla wama-90 nowe-180, i-tumor yaqhubeka nokuncipha ngama-44.8%, igcina impendulo engaphelelanga (PR) ngaphandle kobungozi obukhulu besisu okanye bemithambo-luvo.
Isigulana esineminyaka engama-70 ubudala esinesifo somhlaza wesisu senza utyando ngoFebruwari 2023, emva kotyando sabonisa i-adenocarcinoma enesilonda esiphakathi ukuya kwesahlukileyo kakuhle eyayisele isasazeke kwi-lymph nodes, kwi-peritoneum, nakwimiphunga yomibini, ihamba ne-ascites kunye ne-pleural effusion (isifo esiqhubele phambili, esisasazeke kakhulu). Kwiiveki ezisibhozo emva kotyando, wafumana i-SOX chemotherapy (i-oxaliplatin + S-1), kodwa imeko yakhe yaqhubeka. Imizamo elandelayo nge-PX (paclitaxel) + PD-1 (immunotherapy) imijikelo emine, yalandelwa yi-capecitabine + nivolumab, nayo ayizange ikwazi ukumisa ukuqhubela phambili. Ekugqibeleni, i-nivolumab + fruquintinib (iyeza elichasene ne-angiogenic) yanikwa, kodwa ngempumelelo yayo yayincinci.
Ngomhla wama-28 wonyango lwe-CAR-T, ithumba lalinciphile ngama-47.3% xa kuthelekiswa nonyango lwangaphambi konyango, nto leyo eyabangela impendulo engaphelelanga (PR). Ngomhla wama-60, ithumba laqhubeka lincipha ngama-41.9%, ligcina i-PR eqinisekisiweyo, nto leyo ebonisa unyango oluqhubekayo nolusebenzayo.
Isigulana esineminyaka engama-55 ubudala esinesifo somhlaza wesisu senza i-laparoscopic radical gastrectomy ngoNovemba ka-2023, apho i-postoperative pathology yabonisa i-adenocarcinoma engacacanga kakuhle ene-partial signet-ring cell carcinoma (eyingozi kakhulu). Wazama iindlela ezininzi ze-chemotherapy + immunotherapy, kuquka i-oxaliplatin + capecitabine + sintilimab, i-oxaliplatin + leucovorin + sintilimab, i-nab-paclitaxel + sintilimab + fruquintinib, kunye ne-irinotecan monotherapy. Nangona kunjalo, ngoFebruwari ka-2025, imeko yakhe yaqhubeka ngokukhawuleza, nto leyo eyenza ukuba unyango oluqhelekileyo lungasebenzi.
Emva koko wafumana unyango lweeseli ze-CAR-T, kwaye ngomhla wama-28, ithumba lalinciphile ngama-31.8% xa kuthelekiswa nonyango lwangaphambi konyango, lafumana impendulo engaphelelanga (PR), kwaye ulawulo lwesifo luphumelele.
Okwangoku, kusekho iimvavanyo ezininzi zeklinikhi zobuchwepheshe obutsha bokulwa nomhlaza eTshayina obufuna izigulane. Iingcebiso ngamayeza amatsha kunye nobuchwepheshe, ungaqhagamshelana neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region.
Inombolo yefowuni: 4008803716
I-ID ye-WeChat: 17801183037
I-imeyile：myimmnet@163.com
Ixesha leposi: Julayi-31-2025