Kutshanje, uphando lwe-Antengene's Phase I/II CLINCH lwe-ATG-022 (CLDN18.2 antibody-drug conjugate), isigulane esikhulileyo esinomhlaza wesisu oqhubele phambili kwimigca emininzi ye-chemotherapy, i-immunotherapy kunye nonyango olujoliswe kuyo nangona i-metastases eninzi ifumene impendulo epheleleyo (CR) emva kwe-ATG-022 monotherapy. Imeko yokuba isigulane asinayo i-tumor yaqinisekiswa yi-PET/CT ngoMeyi 2025.
Okwangoku, kusekho iimvavanyo ezininzi zeklinikhi zobuchwepheshe obutsha bokulwa nomhlaza eTshayina obufuna izigulane. Iingcebiso ngamayeza amatsha kunye nobuchwepheshe, ungaqhagamshelana neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region.
Inombolo yefowuni: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
I-ATG-022 yi-CLDN18.2 ADC efunyenwe kwaye yaphuhliswa ngaphakathi yi-Antengene. Kwinkomfa ye-ASCO GI 2025 ekuqaleni kwalo nyaka, i-Antengene ibonise idatha yeklinikhi ehlaziyiweyo ye-ATG-022. Kwizigulane ezine-CLDN18.2 expression ephakathi ukuya kwephezulu (IHC 2+ ≥ 20%), izinga lokuphendula elijolise ngqo (ORR) yayiyi-42.9%, kwaye izinga lokulawula isifo (DCR) yayiyi-95.2%. Phakathi kwezigulane ezine-CLDN18.2 expression ephantsi (IHC 2+ < 20%), i-ORR yayiyi-30.0%, kwaye i-DCR yayiyi-50.0%. Ezi datha zibonisa ukuba i-ATG-022 inikezela ngempumelelo echanekileyo yeklinikhi kunye neprofayili yokhuseleko efanelekileyo kuzo zonke iinkalo ze-CLDN18.2 expression, kubandakanya ukubonakaliswa okuphezulu, okuphantsi, kwanokuphantsi kakhulu. Umsebenzi wayo wokulwa nomhlaza we-wide-spectrum ubonisa ukuba i-ATG-022 inokubonelela ngeengenelo zonyango kubantu abaninzi xa kuthelekiswa nezinye iindlela zonyango ezijoliswe kwi-CLDN18.2. Okwangoku, uphando lokwandiswa kwedosi yeSigaba sesiBini se-ATG-022 luyaqhubeka kwilizwekazi laseTshayina nase-Australia.
Oku kufezekiswa kwe-CR kwesi sigulana sikhulileyo esinomhlaza wesisu kuyakhuthaza kakhulu, kugqamisa amandla okunyanga e-ATG-022 njengonyango olutsha lwe-ADC. Okubalulekileyo kukuba, le ayisiyo yodwa i-CR ebonwe kolu phando luqhubekayo. Ukuza kuthi ga ngoku, kuye kwabonwa amatyala amathathu e-CR, kuquka nezigulana ezivela kwilizwekazi laseTshayina nase-Australia. I-Antengene ijonge phambili ekuboniseni idatha ehlaziyiweyo evela kuphando lwe-ATG-022 kwiNgqungquthela ye-ESMO ezayo ngo-Okthobha ka-2025.
Okwangoku, kusekho iimvavanyo ezininzi zeklinikhi zobuchwepheshe obutsha bokulwa nomhlaza eTshayina obufuna izigulane. Iingcebiso ngamayeza amatsha kunye nobuchwepheshe, ungaqhagamshelana neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region.
Inombolo yefowuni: 4008803716
I-ID ye-WeChat: 17801183037
Email：myimmnet@163.com
Ixesha lokuthumela: Agasti-21-2025