Ngowama-2021, isigulane esineminyaka engama-67 ubudala esinesifo somhlaza wepancreatic senza ummangaliso wezonyango. Emva kotyando, utyando oluninzi lwe-chemotherapy, kunye nokungaphumeleli konyango lwe-TIL, uvavanyo lweklinikhi lwe-TCR-T lwenziwe.Unyango lweeseli awathatha inxaxheba kulo lwenze ukuba i-metastases yemiphunga inciphe ngama-72% kwiinyanga ezi-6. Esi siphumo siphumeleleyo sipapashwe kwiNew England Journal of Medicine, sizisa ithemba elitsha kwizigulana ezineethumba eziqinileyo kwihlabathi liphela.
IZiko leeNgcebiso zaMazwe ngaMazwe leSibhedlele i-Beijing South Suburb Oncology (400 – 880 – 3716) linokwakha ibhulorho yonyango oluphambili lwamazwe ngamazwe lwezigulane ngezixhobo zalo ezizityebi zamazwe ngamazwe kwaye lidlala indima ebalulekileyo kwiingcebiso zamazwe ngamazwe kunye nonyango lwezonyango.
Malunga ne-TCR-TUnyango
I-TCR-TUnyango lweeseli, igama elipheleleyo lalo liyi-T – cell receptor engineered T – cell therapy, yindlela entsha yonyango lweeseli ezithathwa njenge-immunotherapy. Umgaqo wayo ophambili kukukhupha iiseli ze-T emzimbeni wesigulana kunye nokwazisa i-TCR gene enokuqaphela ii-antigen ezithile ze-tumor kwiiseli ze-T ngokusebenzisa ubuchwepheshe bobunjineli be-genetic. Ngenxa yoko, iiseli ze-T eziguquliweyo zinokubona ngokuchanekileyo kwaye zibophe kwii-antigens kumphezulu weeseli ze-tumor, ngaloo ndlela zivuselela umsebenzi wokubulala amajoni omzimba weeseli ze-T kunye nokufezekisa injongo yokuphelisa iiseli ze-tumor.
Ibali Lempumelelo ye-TCR-TUnyango: Ummangaliso Wesigulana EsineKRAS G12D – Umhlaza Wepancreatic Oguqukileyo
Ngaphambi kokuba kufunyaniswe ukuba une-pancreatic head adenocarcinoma, esi sigulana sineminyaka engama-67 ubudala sasihlupheke kakhulu ngenxa yokuhlaselwa rhoqo yi-pancreatitis kunye ne-biliary stricture. Emva kokufunyaniswa, safumana imijikelo emine ye-FOLFIRINOX neoadjuvant chemotherapy regimen, elandelwa kukususwa kotyando kunye ne-chemotherapy eyongezelelweyo. Oku kwenza ukuba imeko yaso ilawulwe ixesha elithile, kwaye ithumba alizange liqhubeke.
Nangona kunjalo, amaxesha amnandi awazange athathe ixesha elide. Ngo-2019, isigulana saba ne-lung metastases, nto leyo ngokungathandabuzekiyo eyaba ngumceli mngeni omkhulu kunyango. Ngo-2020, wathatha inxaxheba kuvavanyo lweklinikhi lwe-tumor - infiltrating lymphocyte therapy, kodwa emva kweenyanga ezintandathu, izilonda ze-lung metastatic zaqhubeka kwakhona, nto leyo ebonisa ukuba iindlela zonyango zangaphambili azikwazanga ukulawula ngempumelelo uphuhliso lwe-tumor.
Xa isigulana sasisele siphelelwe lithemba, ngoMeyi 2021, i-US Food and Drug Administration yavuma isicelo esitsha sophando ngamayeza, esaba yinguqu ebalulekileyo ebomini bakhe - waziswa kwi-TCR-T.unyango lweseli. NgoJuni ka-2021, wafumana unyango lweseli ye-T egazini le-autologous. Okumangalisayo kukuba, emva kwenyanga emva kokufakwa kweseli, izilonda zesifo semiphunga yomguli zehla kakhulu, kwaye ithumba lehla ngama-62%. Emva kwesiqingatha sonyaka, ithumba lehla ngama-72%.
Esi siphumo simangalisayo sonyango sibonisa ngokupheleleyo amandla amakhulu e-TCR-Tunyango lweeseli kunyango lomhlaza.
Kwizigulane ezinomhlaza, ukufumana uxilongo oluchanekileyo kunye nesicwangciso sonyango esingcono kubalulekile. Nangona kunjalo, ngenxa yokwahluka kwamanqanaba ezonyango kunye nobuchwepheshe kwiindawo ezahlukeneyo, izigulane zisenokungakwazi ukufumana iingcebiso zonyango eziphucukileyo kwindawo yazo. Iingxoxo zamazwe ngamazwe zibonelela izigulane ithuba lokunxibelelana neengcali zamazwe ngamazwe, zize zikwazi ukufunda ngeendlela zonyango zamva nje kunye neziphumo zophando kwihlabathi liphela.
Ngokusebenzisa iingxoxo zamazwe ngamazwe, izigulana zinokufumana uvavanyo oluhlukeneyo oluvela kwiingcali ezivela kumazwe ahlukeneyo nakwiindawo ezahlukeneyo. Ezi ngcali zinamava amaninzi ezonyango nolwazi lobungcali kwaye zinokuhlalutya kwaye zigwebe imeko yesigulana ngokweembono ezahlukeneyo ukuze zenze izicwangciso zonyango ezenzelwe wena nezichanekileyo.
Ukongeza, iingxoxo zamazwe ngamazwe zinokunceda izigulane zifunde ngezinye iimvavanyo zonyango kunye neendlela zonyango ezingekaqhutywa eTshayina, nto leyo ebanika ezinye iindlela zonyango.
ISebe leMicimbi yeHlabathi leSibhedlele se-Oncology saseBeijing South Suburb (400 – 880 – 3716) liyazi kakuhle ukubaluleka kokubonisana ngamazwe ngamazwe kwizigulana ezinomhlaza. Ngenxa yoko, lakha iqonga lokutshintshiselana ngezonyango lamazwe ngamazwe ukubonelela izigulana ngeenkonzo zokubonisana zamazwe ngamazwe zobungcali nezisebenzayo. KwiSibhedlele seMicimbi yeHlabathi se-Beijing South Suburb Oncology, izigulana zinokuthatha inxaxheba kwiingxoxo zamazwe ngamazwe nokuba zikwi-intanethi okanye ngaphandle kweintanethi. Iqela lethu lezonyango liza kuqokelela iirekhodi zonyango zesigulana, iingxelo zovavanyo kunye nolunye ulwazi kwangaphambili kwaye liziguqulele kwisiNgesi ukuqinisekisa ukuba iingcali zamazwe ngamazwe zinokuyiqonda ngokupheleleyo imeko yesigulana. Ngexesha lokubonisana, iingcali zamazwe ngamazwe ziya kunxibelelana ubuso ngobuso nesigulana, zibuze imibuzo eneenkcukacha malunga nembali yezonyango yesigulana, iimpawu, kunye nemeko yonyango, kwaye emva koko zidibanise iziphumo zophando lwezonyango zamva nje kunye namava eklinikhi ukuphuhlisa isicwangciso sonyango esifanelekileyo sesigulana.
Kwangaxeshanye, iSebe leHlabathi leBeijing South Suburb Oncology Hospital liza kubonelela izigulana ngeenkonzo ezipheleleyo zoguqulelo kunye nokulungelelanisa ukuqinisekisa inkqubela phambili ethe tye yengcebiso. Emva kwengcebiso, siza kunika ingxelo ngokukhawuleza ngeziphumo zengcebiso kunye neengcebiso zonyango kwisigulana kwaye sinike isikhokelo kunye nenkxaso yonyango olulandelayo.
Ukuze izigulane zikwazi ukufumana iingcebiso zokuxilongwa kunye nonyango lweengcali zamazwe ngamazwe ngokukhawuleza, iSebe leMicimbi yeHlabathi leBeijing South Suburb Oncology Hospital lenze lula inkqubo yenkonzo yokubonisana. Izigulane zifuna kuphela ukufowunela ku-400 – 880 – 3716 kwaye zibonelele ngeerekhodi zonyango ezifanelekileyo kunye neengxelo zovavanyo. Iqela leengcali leSebe leMicimbi yeHlabathi leBeijing South Suburb Oncology Hospital liza kulungiselela ingcali efanelekileyo yamazwe ngamazwe ukuze isigulane sibonisene ngexesha elifutshane. Ngexesha lokubonisana, iqela leengcali zokuguqulela liza kuqinisekisa unxibelelwano oluhamba kakuhle noluchanekileyo phakathi koogqirha kunye nezigulane, nto leyo evumela izigulane ukuba ziqonde ngokucacileyo izimvo kunye neengcebiso zeengcali. Ukongeza, iSebe leMicimbi yeHlabathi leBeijing South Suburb Oncology Hospital linokunceda izigulane ekuphatheni iinkqubo zokudlulisela, ukulungiselela iindlela zokuhamba, njl.njl., ukubonelela ngeenkonzo zokumisa kanye.
Ukwabelana ngeTyala kunye nokuphefumlelwa
Ukongeza kwimeko engentla yesigulana esine-KRAS G12D – umhlaza wepancreatic oguqukileyo, iSebe leHlabathi leBeijing South Suburb Oncology Hospital likwancede izigulane zomhlaza zamanye amazwe ukuba zifumane iziphumo ezilungileyo zonyango ngonyango eTshayina.
NgoJuni ka-2024, isigulane somhlaza wemiphunga esingesiso iseli encinci esivela eMntla Korea sacela uncedo lwethu. Umhlaza wemiphunga ngomnye weethumba ezinobungozi ezinezinga eliphezulu lokwanda kwaso kwihlabathi liphela naseTshayina. Ngo-2022, bekukho malunga ne-1.06 yezigidi zamatyala amatsha kunye nokufa okumalunga nama-740,000 ngenxa yomhlaza wemiphunga eTshayina, phakathi kwazo umhlaza wemiphunga ongesiso iseli encinci (i-NSCLC) umalunga nama-80% ukuya kuma-85%.
Isigulana sasinotshintsho lwe-EGFR kwaye safumana unyango olufana ne-afatinib kunye ne-osimertinib. Nangona sasifumene unyango olwahlukeneyo, iindaba ezimbi zafika ngoMeyi 2024, kwaye imeko yesigulana yaqhubeka. Ngoko ke weza eTshayina ukuze asincede.
Emva kovavanyo, ukubonakala kwe-mesothelin (MSLN) yesigulana kwakuyi-75%. Emva koko sanceda isigulana ukuba sifumane isicwangciso sonyango samva nje kulo lonke ilizwe. Ngoku imeko yesigulana ithomalalisiwe, kwaye amaqhuqhuva emiphungeni anciphile, njengoko kubonisiwe kumfanekiso ongezantsi.
Eli tyala lisixelela ukuba kubantu abanesifo somhlaza, akufuneki bayeke lula ithuba lonyango. Nokuba unyango lwasekhaya lusengxakini, banokuqonda iindlela zonyango zamva nje zamazwe ngamazwe kunye neziphumo zophando ngokusebenzisa iingxoxo zamazwe ngamazwe kwaye bazame ukufumana amathuba amaninzi onyango kubo.
Indlela yokuqhagamshelana neSebe leHlabathi leSibhedlele se-Oncology saseBeijing South Suburb
Ukuba wena okanye amalungu osapho lwakho ninesifo somhlaza kwaye ninethemba lokufunda ngeendlela zonyango ezisemgangathweni zamazwe ngamazwe okanye nifune iingcebiso zokuxilongwa kunye nonyango lweengcali zamazwe ngamazwe, nceda utsalele umnxeba kwinombolo yefowuni yeSebe leHlabathi leBeijing South Suburb Oncology Hospital (400 – 880 – 3716). Iqela leengcali liza kuphendula imibuzo yakho, lilungiselele iingxoxo zamazwe ngamazwe, kwaye likunike inkxaso kunye noncedo olupheleleyo.
Unyango lomhlaza ludabi elide nelinzima, kodwa sikholelwa ukuba ngenkqubela phambili eqhubekayo yetekhnoloji yezonyango, izigulane ezininzi ezinomhlaza ziya kukwazi ukoyisa esi sifo kwaye ziphinde ziphile kwakhona. ISebe leMicimbi yezeNtsholongwane laseBeijing South Suburb liza kuqhubeka lizama ukuphucula umgangatho walo wenkonzo kunye nezakhono zonyango kwaye libonelele ngeenkonzo zonyango ezisemgangathweni ophezulu kwizigulane ezininzi ezinomhlaza. Masisebenze kunye ukuze silwe nomhlaza kunye nokudala imimangaliso yobomi!
Okwangoku, kusekho iimvavanyo ezininzi zeklinikhi zobuchwepheshe obutsha bokulwa nomhlaza eTshayina obufuna izigulane. Iingcebiso ngamayeza amatsha kunye nobuchwepheshe, ungaqhagamshelana neSebe leMicimbi yeZibhedlele ze-Oncology zaseBeijing South Region.
Inombolo yefowuni: 4008803716
Email：myimmnet@163.com
Ixesha leposi: Meyi-15-2025