Unyango olutsha lwe-HIFU non-invasive-ultrasound olusandul’ ukwaziswa kwiBeijing Puhua International Hospital (BPIH) luneengenelo ezibalulekileyo kuneenkqubo ezisetyenziswa rhoqo ekunyangeni umhlaza wepancreatic.
Umhlaza wePancreatic kunye ne-High Intensity Focused Ultrasound Ablation (HIFU)
Umhlaza wePancreatic
Ukuxilongwa kwangoko komhlaza wepancreatic kunzima kakhulu. Ngumhlaza onobungozi kakhulu odla ngokuba neziphumo ezibi. IiNational Institutes of Health zibika ukuba izinga lokusinda lonyaka omnye kumhlaza wepancreatic yi-8% kuphela, izinga lokusinda leminyaka emi-5 lingaphantsi kwe-5%, kwaye umyinge wobomi obulindelekileyo ziinyanga ezi-2 ukuya kwezi-3. Uninzi lwezigulane luhlala luchongwa kuphela kwinqanaba eliphezulu lesi sifo, njengoko iimpawu zomhlaza wepancreatic zihlala zibonakala kuphela xa isifo siqhubekile. Iimpawu ziquka iintlungu zesisu, ukwehla kobunzima obungachazwanga kunye nobunzima bokugaya ukutya okunamafutha. Kwinqanaba eliphezulu iimpawu zentlungu enzima esezantsi komqolo zichaphazela kakhulu umgangatho wobomi besigulana kwaye ukusetyenziswa kwamayeza okuthomalalisa iintlungu kunokubonelela ngesiqabu, kodwa ngesiqhelo akwanelanga.
Ngaphezu koko kwinqanaba eliphezulu lesi sifo, ukhetho lotyando lusenokungasebenzi kwaye kwiimeko ezininzi unyango oluqhelekileyo kunye ne-chemotherapy luzisa iziphumo ebezingalindelekanga ezininzi kunye nobutyhefu.
Unyango olutsha lwe-HIFU non-invasive-ultrasound olusandul’ ukwaziswa kwiBeijing Puhua International Hospital (BPIH) luneengenelo ezibalulekileyo kuneenkqubo ezisetyenziswa rhoqo ekunyangeni umhlaza wepancreatic.
Kwizigulane ezinomhlaza wepancreatic okwinqanaba lokuqala, i-HIFU inokususa ngokupheleleyo isilonda. Kwizigulane ezinomhlaza wepancreatic okwinqanaba eliphakathi okanye eliphambili, unyango lwe-HIFU lunokunciphisa ngoko nangoko iintlungu ezinzima zesisu kunye nomqolo ongezantsi ezibangelwa ngumhlaza wepancreatic.
Yintoni i-HIFU?
I-HIFU sisishunqulelo segama elithi "high-intensity focused ultrasound ablation" kwaye simele isizukulwana esilandelayo se-"unyango lomhlaza olungenazo iindlela ezininzi.
Ukusetyenziswa kwe-HIFU Ukungena kakuhle kwe-ultrasound, kunye nobukhali bayo njengoko umqadi we-ultrasound uhamba kwi-probe ye-transducer kwaye ugxile kwindawo ethile, ujolise ngqo kwi-tumor, eshushu phakathi kwama-60 ukuya kwi-100 degrees Celsius. Iiproteni zeseli ze-tumor ziyaqina nto leyo ekhokelela ekutshatyalalisweni kwe-tumor (ukutshatyalaliswa kobushushu bezicubu), ngaphandle kokuba izicubu ezijikelezileyo zonzakaliswe. Izicubu ze-tumor ezifileyo emva koko ziphinda zifunxwe ngumzimba kancinci kancinci.
Kwimeko yomhlaza wepancreatic ongasebenziyo, unyango lwe-HIFU lunokunciphisa ngempumelelo umthwalo we-tumor kwaye lunciphise iintlungu ze-tumor ngokususa izicubu, ukunciphisa ubunzima be-tumor kunye nokuguqulwa kwe-neurotransmitter, ngaloo ndlela kwandisa ixesha lokuphila kwesigulane kunye nokuphucula umgangatho wobomi.
Emva konyango, ama-88% ezigulana afumene amanqanaba ahlukeneyo okunciphisa iintlungu,
ngaphandle kweengxaki ezinkulu ezifana nokopha kwegazi kwisisu esingaphezulu okanye ukugqobhoka kwesisu namathumbu kunye ne-MRI scans ephuculweyo ityhila ukususwa kwezicubu okusebenzayo kwindawo yonyango lwe-HIFU.
Emva kokwenza uphando olunzulu nophuhliso, unyango lwe-HIFU luye lwamkelwe kwaye lwakhuthazwa kunyango lomhlaza wepancreatic.
Ngenxa yokuba ayingenisi ntsholongwane, utyando kwiimeko ezininzi luye lwathintelwa kwaye uninzi lwezigulane lufuna unyango olunye lwe-HIFU ukuze kufezekiswe iziphumo ezinqwenelekayo zokutshatyalaliswa kwesimila. Okumangalisayo kukuba, emva kosuku olunye lokufumana unyango, uninzi lwezigulane lunokubuyela emakhaya, kuba akukho ziphumo emva koko ezichaphazela impilo yezigulane.
Ukuthelekiswa kwe-HIFU kunye neendlela zonyango ezisemgangathweni
Ngelishwa, i-70% – 80% yezigulane ezinomhlaza we-pancreatic azifumani zimpawu ekuqaleni kwale meko. Xa kufunyenwe umhlaza we-pancreatic, isigulane sidla ngokuba sele sifikelele kwinqanaba eliphakathi okanye eliphambili lale meko, kunye nexesha eliqhelekileyo lokuphila eliyinyanga ezi-3-6 kuphela. Nje ukuba kufunyaniswe ukuba unesifo, ngaphantsi kwe-10% yezigulane ezinomhlaza we-pancreatic zifanelekile utyando, nto leyo ebangela intlungu kwaye idla ngokwandisa ubomi besigulana ukuya kuthi ga kwiinyanga ezili-9 kuphela. Nokuba zidibene ne-radiotherapy kunye ne-chemotherapy, ixesha lokusinda lidla ngokwandiswa kuphela ngeenyanga ezili-0.5-1 ezongezelelweyo. Iindlela zonyango eziqhelekileyo zibiza kakhulu kwaye azisebenzi, njengoko zingayi kwandisa ixesha lokuphila kwaye zinike isiqabu kwintlungu yesigulana.
Nangona kunjalo, phantse bonke abaguli abanomhlaza wepancreatic bafanelekile ukufumana unyango lwe-HIFU olungenalo uhlaselo nolunomngcipheko omncinci.
Ngokwezibalo zethu, ukusinda kwezigulane kunokwandiswa ukusuka kwiinyanga ezi-3 ukuya kwezi-6 ukuya kunyaka omnye ukuya kwemibini kwaye i-98% yezigulane zifumana uphuculo olubonakalayo ekunciphiseni iintlungu kunye nokwandiswa kobomi emva kokufumana unyango lwe-HIFU!
Iingenelo ze-HIFU Ultrasound Ablation Therapy
1.Unyango olungangenisi gazi ukugcina amalungu omzimba kunye nezakhiwo, ngaphandle kotofelo-gazi kunye nokukhanya kwelanga.
2.Imodyuli yokujolisa ye-3D ichaza umda weethumba kwaye ibala isicwangciso sonyango se-3D, isoloko ijonga iimpendulo zezicubu kwaye ilungisa iiparameter zonyango ngokufanelekileyo, ifezekisa iprotokholi yonyango lomntu ngamnye.
3.Ukususwa okufanelekileyo nokuchanekileyo. Ngempazamo yokuqokelelwa kwe-plus kunye ne-minus 1mm, intshukumo echanekileyo yenkqubo yokunyakaza enemilinganiselo emi-6 inokuphelisa iithumba ezikufutshane nemithambo emikhulu okanye imithambo-luvo ngokukhuselekileyo.
4.Kwiimeko ezininzi kufuneka iseshoni enye yonyango kwaye akukho mida ngenxa yobukhulu bethumba kunye nokuma kwalo. Umda phakathi kwezicubu ezinyangiweyo kunye nezinganyangwanga unokuba mxinwa njengeeseli ezi-6 ukuya kwezi-10 ububanzi.
5.Unyango olukhokelwa yi-ultrasound olusebenzisa i-doppler yemibala ngexesha langempela olunohlalutyo lwedijithali oluvumela ukujonga ngexesha lonke lonyango kwaye lubonelela ngomfanekiso we-ultrasound okhawulezileyo ukuvavanya iziphumo zizonke emva konyango.
6.Amandla ommandla ogxileyo aphezulu ngokwaneleyo ukuba abangele ubuthi obuvela kubushushu obukhawulezileyo (ubushushu obungaphezulu kwama-56Derees Celsius) obuya kubangela i-coagulative necrosis engenakuguqulwa.
7.Ukusebenza kwenkqubo yomzimba yokuzikhusela, njengoko izicubu ezifileyo zisuswa ngumzimba ngokwawo.