Uhlelo lwamva nje loHlelo loMbutho wezeMpilo weHlabathi woHlelo lweSoft Tissue kunye neBone Tumors, epapashwe ngo-Epreli ka-2020, luhlelaii-sarcomaskwiindidi ezintathu: samathumba amaninzi eethishu, amathumba ethambo, kunye namathumba awo omabini amathambo kunye nezicubu ezithambileyo ezineeseli ezincinci ezingqukuva ezingahlukanisiweyo.(ezifana ne-EWSR1-non-ETS fusion round cell sarcoma).
“Umhlaza Olityelweyo”
I-Sarcoma luhlobo olunqabileyo lweumhlaza kubantu abadala, ukubala malunga1%yawo yonke imihlaza yabantu abadala, edla ngokubizwa ngokuba “nguMhlaza olityelweyo.”Noko ke, ngokwentelekisoeqhelekileyo ebantwaneni, ukubalwa ngeenxa zonke15% ukuya kwi-20%yazo zonke izifo zomhlaza zabantwana.Ingenzeka nakweliphi na ilungu lomzimba, ngokuqhelekileyo kwiiingalo okanye imilenze(60%), ilandelwa yiisiqu okanye isisu(30%), kwaye ekugqibeleniintloko okanye intamo(10%).
Kwiminyaka yakutshanje, izehlo zethambo kunye nezicubu ezithambileyo ziye zanda ngokuthe ngcembe.Izicubu zethambo ezinobungozi eziphambili zixhaphake kakhulu kulutsha kunye nabantu abakwiminyaka ephakathi kwaye ziquka i-osteosarcoma, i-Ewing sarcoma, i-chondrosarcoma, i-malignant fibrous histiocytoma, kunye ne-chordoma, phakathi kwabanye.Izibilini ezithambileyo eziqhelekileyo ezinobungozi ziquka i-synovial sarcoma, i-fibrosarcoma, i-liposarcoma, kunye ne-rhabdomyosarcoma.I-Bone metastases ixhaphake kakhulu kubantu abakwiminyaka ephakathi kunye nabasele bekhulile, kunye namathumba aphambili aqhelekileyo ngumhlaza wemiphunga, umhlaza wamabele, umhlaza wezintso, umhlaza wesibeleko, kunye nomhlaza wegilo, phakathi kwabanye.
Ukufunyaniswa kwangethuba, unyango lwangethuba-Ukukhanyisela “iithumba” ezifihlakeleyo.
Ngenxa yezinga eliphezulu lokuphindaphinda kwe-sarcomas, amathumba amaninzi anoxilongo olungacacanga lwangaphambi kotyando kwaye alunazo iimvavanyo ezineenkcukacha.Oku kudla ngokukhokelela ekufumaneni ngexesha lotyando ukuba ithumba alilulanga njengoko kuqikelelwa kwangaphambili, okukhokelela ekuphumeni okungaphelelanga.Ukuphindaphinda emva kokuhlinzwa okanye i-metastasis inokuthi yenzeke, ibangela ukuba izigulane ziphose ithuba lonyango elilelona lifanelekileyo.Ngoko ke,ukufunyaniswa kwangethuba, ukuxilongwa ngokuchanekileyo, kunye nonyango lwangexesha kunempembelelo ebaluleke kakhulu kwi-prognosis yezigulane. Namhlanje, singathanda ukwazisa ingcali ebekekileyo ephantse yangama-20 eminyaka yamavakuxilongo olusemgangathweni kunye nonyango lomntu lwe-soft tissue sarcoma, kwaye ivunyiwe kakhulu ngamashishini kunye nezigulana -GqirhaULiu JiayongkwiSebe leBone kunye ne-Soft Tissue kwiSibhedlele soMhlaza seYunivesithi yasePeking.
Ukutyhila iNgcali enolwazi olunzulu lwethambo kunye neentlungu zenyama - uGqr.ULiu Jiayong
Ugqirha wezoNyango, uGqirha oyiNtloko, uNjingalwazi oNxibeleleyo.Ufunde kwiziko lomhlaza laseAnderson eUnited States.
Ubungcali:Unyango olubanzi lwe-sarcomas yezicubu ezithambileyo (ukuhlinzwa ngokutsha kunye nokwakhiwa kwakhona; i-chemotherapy, unyango olujoliswe kuyo, kunye ne-immunotherapy);unyango lotyando melanomas.
Ngokumalunga neminyaka engama-20 yamava ezonyango, uGqirha Liu Jiayong uqokelele ubuchwephesha bonyango kunye nonyango lotyando kunyango.ukuxilongwa okusemgangathweni kunye nezicwangciso zonyango zomntukwiisarcomas ezithambileyo eziqhelekileyo ezifana ne-pleomorphic sarcoma, i-liposarcoma, i-leiomyosarcoma, i-synovial sarcoma, i-adenocystic carcinoma-like sarcoma, i-epithelioid sarcoma, i-fibrosarcoma, i-angiosarcoma, kunye ne-fibromatosis ye-infiltrative.Unguye ngokukodwanobuchule bokuphatha imithambo yegazi kunye nemithambo-luvo ngexesha lokususwa kwe-sarcoma yamalungu, kunye nokulungisa nokuvuselela iziphene ezithambileyo eluswini.Ugqirha uLiu umamela isigulana ngasinye ngomonde, abuze ngononophelo ngembali yaso yonyango, kwaye uthatha iirekhodi zonyango ngononophelo.Uhlawula ingqalelo ekhethekileyo kwiinguqu kwimeko yesigulane ngamaxesha ahlukeneyo, njengangaphambi nangemva kokuhlinzwa, ngexesha lokunyanga, ukulandelwa, kunye nokuqhubela phambili kwesifo, ukwenza izigwebo ezichanekileyo kunye nokulungelelaniswa kwexesha elifanelekileyo kwizicwangciso zonyango.
Ugqirha uLiu Jiayong ngoku ukhonza njengelungu leSoft Tissue Sarcoma kunye neQela leMelanoma loMbutho waseTshayina wokulwa nomhlaza, kunye nelungu leQela leBone Tumor yeBeijing Society of Orthopedics yoMbutho wezoNyango waseTshayina.Kwi-2010, wayengowokuqala e-China ukuguqulela kunye nokupapasha "Izikhokelo ze-NCCN zeClinical Practice kwi-Soft Tissue Sarcoma," ukukhuthaza unyango olubanzi olusemgangathweni lwe-sarcomas yezicubu ezithambileyo.Uyaqhubeka nokuzabalazela ukuqhubela phambili kuphando lweklinikhi kunye nesayensi, nangona unomthwalo omkhulu wesigulane.Uzinikezele kwaye unoxanduva lwesigulana ngasinye asinyangayo, kwaye ngexesha lo bhubhani, wajongana nobunzima obujongene nezigulana ezifuna unyango ngokusabela ngokukhawuleza kudliwano-ndlebe nezigulana, ukuphonononga iziphumo zokulandelela, kunye nokubonelela ngeengcebiso ezifanelekileyo zonyango ngokusebenzisa amaqonga othethwano kwi-intanethi anje Iqela lesigulane sikaGqirha olungileyo.
Ityala lakutshanje
UMnu Zhang, isigulane esineminyaka engama-35 ubudala, ngokukhawuleza wafumana ukulahleka kombono ekuqaleni kwe-2019. Emva koko, wenza utyando lwe-enucleation ekhohlo ngenxa yokunyuka okuqhubekayo kwengcinezelo ye-intraocular.I-postoperative pathology ibonakalise i-pseudotumor evuthayo.Ngehlobo lalo nyaka mnye, amaqhuqhuva amaninzi emiphunga afunyenwe ngexesha lovavanyo olulandelelweyo, kodwa akukho seli zethumba zifunyenwe ngeenaliti ze-biopsies.Uvavanyo olongezelelweyo oluthe kratya lwabonisa ukuba kukho i-metastases ezininzi zamathambo nemiphunga.Uthethwano kwizibhedlele zasekhaya nezikwinqanaba eliphezulu zafumanisa ukuba unethumba elidumbayo le-myofibroblastic.Ngo-Agasti ka-2022, wenziwa i-chemotherapy yedosi ephezulu, eyathi yathomalalisa iintlungu zakhe kodwa ingabonakalisi mpucuko kwizilonda xa ephinda ephononongwa.Nemeko yakhe yomzimba yaba buthathaka.Nangona kunjalo, intsapho yakhe ayizange ilahle ithemba.Emva kokufuna izimvo ezininzi, beza kuGqirha Liu Jiayong ingqalelo ngoNovemba 2022. Emva kokuphonononga ngononophelo imbali yezonyango yesigulane, zonke iirekhodi zonyango, iimvavanyo ze-pathological, kunye nedatha yokucinga,GqirhaU-Liu wenze isiphakamiso serejimeni ye-chemotherapy ebandakanya idosi ephantsi ye-methotrexate kunye ne-Changchun Ruibin.Le rejimeni yechemotherapy ineendleko ezisebenzayo kwaye ineziphumo ebezingalindelekanga ezincinci.Emva kweentsuku ezingama-35 zamayeza, i-CT scan elandelelweyo ibonise ukuba ubunzima kwimiphunga elungileyo yanyamalala, ebonisa ulawulo olululo lwethumba.Uvavanyo olulandelelweyo lwakutsha nje kwiSibhedlele saseBeijing soMmandla we-Oncology ubonise imeko yemiphunga ezinzile, kwaye uGqirha uLiu ucebise ukutyelelwa rhoqo.Ngoku umguli nentsapho yakhe banentembelo engakumbi kunyango olulandelayo, bezaliswe lithemba.Bavakalelwa kukuba baye babona ilitha lokukhanya kuhambo lonyango baza bavakalisa umbulelo wabo osuk’ entliziyweni ngokubonisa uxabiso lwesilika.
Ixesha lokuposa: Aug-25-2023